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Bipolar and Genetics

Genetic Research and Bipolar Disorder Amy Pattishall   Penn State College of Medicine 2002   Bipolar Disorder Affective disorder characterized by recurrent manic and depressive episodes. High level of psychiatric service use and morbidity. About 15% suicide rate among bipolar disorder patients. Variable age of onset, mean age of onset is 21. A great amount of anatomical, biochemical, genetic and pharmacologic data on the disorder, however no theory unifies this data. Etiology Stress-Diathesis Model Environmental Stressors: Death of a loved one Job/School setback Relationship problems Drug Use Acquired Vulnerabilities: Medical illnesses that affect well-being/brain function Psychobiological sequelae of abuse, parental loss, trauma Genetic Background   Genetics Concordance rates: Monozygotic  56-80% Dizygotic          14-25% Lifetime risk of first degree relatives 5-10% Lifetime risk of general population: 0.5-1.5% Rates are similar in males and females   Family Studies Craddock and Jones Compilation of studies which measured lifetime risk of bipolar disorder in first degree relatives of bipolar proband in which DSM IV criteria for bipolar I was used and some of the relatives were interviewed directly. Findings: Increased relative risk of Bipolar I in relatives of proband Odds Ratio of 7 First degree relatives of bipolar probands have increased risk of unipolar major depression (evidence shows 2/3-3/4 of cases may be bipolar genetically). Bipolar II disorder occurs more frequently, as does schizoaffective disorder with manic features. Lifetime risk of affective disorder increases with: Early age of onset Number of affected relatives Unknown whether risk varies according to type of relative.   Twin Studies 6 studies using the DSM IV criteria for Bipolar Disorder were pooled   Relationship to Proband            Risk of Bipolar...

Your Child Does Not Have Bipolar Disorder

Have you been told your child has bipolar disorder? Do you wonder whether your child has been correctly diagnosed? Are you reluctant to give your child medications? Do you want to understand the scientific evidence for the disorder and its treatment?

Asperger’s Disorder Review

This disorder did fall under the category of Pervasive Developmental Disorders in which Autistic Disorder, Rett’s Disorder, Childhood Disintegrative Disorder and PDD NOS also fell under. The classification is now revised.

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