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PANDAS

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections

The Child Advocate is devoted to children and the parents and professionals that work with them and advocate for them.  Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections or PANDAS is an unusual process that physicians are just learning more about.  PANDAS can imitate, exacerbate or cause any number of psychiatric conditions.  PANS is a newer term used to describe the larger class of acute-onset OCD or related cases. PANS stands for Pediatric Acute-onset Neuropsychiatric Syndrome and includes all cases of abrupt onset OCD, not just those associated with streptococcal infections.The following are some current concepts and links to learn more.

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PANDAS and First-Degree Relatives

Psychiatric Disorders in First-Degree Relatives of Children with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) 3 (A journal article by Lougee, Perlmutter, Nicolson, Garvey, and Swedo)  This Article Review is presented by Patrick W. Joyner, M.S.  The Pennsylvania State University – College of Medicine 2006 Introduction:  The goal of this article is to determine the rates of psychiatric disorders in the first-degree relatives of children with obsessive-compulsive disorder (OCD) and/or tics secondary to a Group A β-hemolytic Streptococcus (GABHS) infection.   Hypothesis:  The rates of OCD and tic disorders would be increased among the first-degree relatives of the PANDAS probands and that the findings would replicate previous family studies of probands with OCD and/or tic disorders; but not isolated to the PANDAS subgroup.   What is PANDAS? Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. More specifically, a subgroup of pediatric patients with the sudden onset and/or acute exacerbations of tics and/or obsessive-compulsive symptoms that follow infections with GABHS.                                                               This subgroup is unique in age of presenting symptoms (3-12 years old)                                                             The course of their symptoms; relapsing and remitting (i.e. sawtooth pattern if graphed longitudinally). iii.      Presence of choreiform movements (95% in acutely ill patients). Choreiform Movements – an isolated finding of fine piano playing movements of the fingers that is not present at rest and only elicited via stressed postures. Choreatic Movements (i.e. Syndenham’s Chorea) – writhing adventitious movements that are accompanied by a failure to sustain tetanic contractions and muscle weakness; as well are present continuously and increase with unrelated voluntary movements.                                                           Abrupt onset of symptoms (an overnight explosion of symptoms that can...